The Science Behind NAD+ Supplements: Can They Really Boost Your Energy and Youthfulness?

hands holding a model of a molecule

In the world of longevity, few molecules have received as much attention as NAD+ (nicotinamide adenine dinucleotide)—and for good reason. This essential coenzyme plays a vital role in converting food into energy, supporting cellular repair, and maintaining healthy aging. 

Unfortunately, as we get older, NAD+ levels naturally decline, which may contribute to fatigue, slower recovery, and signs of aging like brain fog or decreased resilience.    

 

What is NAD+? 

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell of your body. It plays a central role in turning nutrients into energy and is essential for the function of sirtuins—proteins involved in DNA repair, inflammation control, and aging. 

 

What Drains Your NAD+ Levels? 

In addition to the natural decline that comes with age, several factors can accelerate the loss of NAD+ in the body, including: 

  • Chronic stress 
  • Poor sleep 
  • Excess alcohol 
  • High blood sugar 
  • UV exposure and oxidative stress 
  • Illness or inflammation 

 

Why Does it Matter?  

When NAD+ levels drop, your cells can’t produce energy efficiently, repair DNA damage or respond to inflammation the way they should.  This can lead to signs of early aging like fatigue, brain fog, slower recovery from workouts or illness and reduced resilience under stress. 

  

What you can do:    

Because oral NAD+ is poorly absorbed, NAD+ Nasal Spray offers a more efficient way to support levels. It bypasses digestion, allowing quicker, more direct uptake.   Studies suggest intranasal delivery of NAD+ can significantly raise NAD+ levels in the brain, offering promising benefits for supporting energy, brain recovery and healthy aging. 

  

Who Might Benefit? 

  • Adults over 40 noticing decreased energy or slower recovery 
  • Anyone seeking proactive aging support 
  • Individuals with high-stress lifestyles or demanding physical routines 
  • People looking for long-term cellular and brain health support 

 

Bottom Line 

NAD+ is essential to how your body ages and functions. With levels naturally declining over time, supporting NAD+ is about more than energy, it’s about protecting the health and longevity of every cell in your body. 

References:

  1. Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD⁺ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021;22(2):119-141. doi:10.1038/s41580-020-00313-x 
  2. Radenkovic D, Aguilar‑Mazada C, Cortez‑Domínguez L, et al. Clinical evidence for targeting NAD⁺ therapeutically. Pharmaceuticals (Basel). 2020;13(9):247. doi:10.3390/ph13090247. PubMed PMID: 32942582. PubMed Central PMCID: PMC7558103. 
  3. Ying W, Garnier P, Swanson RA. NAD⁺ as a metabolic link between DNA damage and cell death. J Neurosci. 2007;27(33):8866-8875. doi:10.1523/JNEUROSCI.1766-07.2007 
  4. Zhang J, Xie X, Tang M, et al. Intranasal administration of NAD⁺ profoundly decreases brain injury in a rat model of stroke. Front Neurosci. 2016;10:145. doi:10.3389/fnins.2016.00145 
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