Support Your Body on Semaglutide

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How to Support Your Body While Taking Semaglutide: Nutrition, Hydration, Movement 

Whether you’re taking Ozempic®, Wegovy®, or another GLP-1 medication, supporting your body on semaglutide is just as important as the medication itself. Semaglutide can be a powerful tool for weight loss and blood sugar control, but it may come with side effects that can be managed through simple lifestyle strategies.

In this post, we’ll cover key tips for supporting your body on semaglutide—from managing side effects to maximizing results—focusing on nutrition, hydration, and movement.

 

Nutrition on GLP-1: What to Eat on Semaglutide 

One of the most common questions from patients is: “What should I eat while taking Semaglutide?” The answer is simple – eat to support your digestion, blood sugar, and energy levels. 

Here’s what to focus on: 

  • High-protein meals to preserve lean muscle and keep you fuller longer 
  • Fiber-rich vegetables to support digestion and prevent constipation 
  • Low-glycemic carbs like quinoa, oats, lentils, and sweet potatoes to support blood sugar stability 
  • Healthy fats from avocado, nuts, olive oil, and seeds for hormone balance and satiety 

Avoid or minimize: 

  • Greasy, high-fat foods – These can worsen nausea due to slow digestion 
  • Highly processed foods – May cause GI discomfort and blood sugar spikes 
  • Large meals – Semaglutide slows gastric emptying, so smaller portions are easier on your stomach 

Semaglutide reduces appetite, so be intentional about choosing nutrient-dense foods even when you don’t feel very hungry. 

 

Staying Hydrated on Ozempic & Other GLP-1s 

Hydration is essential for anyone on Semaglutide, especially if you’re experiencing nausea, constipation, or reduced food intake. Many people don’t realize how much water they’re not getting once their appetite drops. 

Semaglutide Hydration Tips: 

  • Aim for at least 2–3 liters of water per day 
  • Include low-sugar electrolyte powders, especially if you live in a warm climate 
  • Sip slowly throughout the day rather than chugging all at once to avoid GI discomfort 
  • Add herbal teas, broth, or infused water if plain water feels boring or hard to drink 

 

 Movement Matters: Exercise While on Semaglutide 

Physical activity is important for maintaining muscle, improving insulin sensitivity, and supporting mental health. Even light movement can help reduce some side effects like fatigue, constipation, or low mood. 

Movement strategies: 

  • Start with daily walking, even if it’s just 10–20 minutes at a time 
  • Add resistance training 2–3x/week to protect muscle during weight loss 
  • Use gentle yoga or stretching on days when you feel sluggish 
  • Listen to your body: low intensity is better than nothing, especially during adjustment phases 

 

Bonus Semaglutide Support Tips 

  • Eat small, frequent meals if large meals cause nausea or fullness 
  • Stay upright after eating to reduce reflux or indigestion 
  • Prioritize sleep: Your body needs time to recover and regulate appetite hormones 
  • Limit alcohol: It can worsen GI symptoms and impact blood sugar 
  • Track your food and hydration to stay consistent even when your appetite drops 

 

Final Thoughts 

Taking Semaglutide can be life-changing, but the best results come from supporting your body on Semaglutide with healthy, sustainable habits. Focusing on balanced nutrition, daily hydration, and gentle movement enhances the medication’s benefits while minimizing common side effects like nausea or fatigue.

Supporting your body on Semaglutide isn’t about strict rules—it’s about simple, consistent actions that boost energy, improve mood, and make results more sustainable. By combining Semaglutide with lifestyle habits that care for your whole body, you’ll maximize your success and feel your best throughout the journey.

References:

Amaro A, Sugimoto D, Wharton S. Efficacy and safety of semaglutide for weight management: evidence from the STEP program. Postgrad Med. 2022 Jan;134(sup1):5-17. doi: 10.1080/00325481.2022.2147326. PMID: 36691309. 

Mozaffarian D, Agarwal M, Aggarwal M, Alexander L, Apovian CM, Bindlish S, Bonnet J, Butsch WS, Christensen S, Gianos E, Gulati M, Gupta A, Horn D, Kane RM, Saluja J, Sannidhi D, Fatima Cody S, Callahan EA. Nutritional Priorities to Support GLP-1 Therapy for Obesity: A Joint Advisory From the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and the Obesity Society. Am J Lifestyle Med. 2025 May 30:15598276251344827. doi: 10.1177/15598276251344827. Epub ahead of print. PMID: 40452753; PMCID: PMC12125019. 

 

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It is essential to have a nutritionist as part of your team. So, when I found out you get a complimentary nutritionist consultations with PHRx program...you know I hopped on top of that.

... Chanel, PHRx verified customer

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We can answer your questions.

Check out our full list of FAQs.

We offer a comprehensive approach to your weight loss journey, combining effective GLP-1 medications with personalized supplements to support both your health and goals. Our focus is on enhancing the effectiveness of your treatment plan while promoting overall well-being. Through our physician affiliates, we provide convenient telehealth services for screening and approval, and our supplements are thoughtfully selected in partnership with Persona Nutrition to complement your weight loss progress.

Getting started is easy! Simply complete a brief health assessment through our telehealth platform. A licensed healthcare provider will review your information to determine if you qualify for GLP-1 therapy. If approved, your prescription will be sent directly to you. Additionally, we'll arrange a supplement consultation through our partnership with Persona Nutrition to create a customized supplement plan tailored to your needs.

GLP-1 (glucagon-like peptide-1) medications, including semaglutide and tirzepatide, are prescribed to manage blood sugar levels and support weight loss. These medications work by mimicking natural hormones that regulate appetite and insulin production. This helps you feel fuller for longer, supports healthy blood sugar levels, and promotes weight loss when used alongside a balanced diet and regular exercise.

Our licensed healthcare providers prescribe a variety of medications tailored to your unique needs, including FDA-approved anti-obesity medications and certain off-label medications for weight loss. We also offer compounded medications, prepared by 503A and 503B pharmacies that follow stringent standards set by the FDA. However, please note that while these pharmacies adhere to FDA guidelines, compounded medications are not reviewed or approved by the FDA for safety, efficacy, or intended use.

As with any medication, side effects may occur. The most common side effects of GLP-1 agonists include GI effects. For most users, these side effects are resolved within a few weeks. However, it’s important to inform your healthcare provider if you experience any issues while taking a new medication.

If you don’t qualify for GLP-1 medications or prefer not to use them, we offer personalized nutrition support through our partner, Persona Nutrition. Their team can help you explore natural alternatives and supplements that support weight management and metabolic health. Whether you choose to focus on natural solutions alone or in combination with your medications, we’ll work with you to create a plan tailored to your needs.

Pricing varies based on your personalized treatment plan and includes the cost of your medication, unlimited access to your medical provider, and consultations with a nutritionist. We offer transparent out-of-pocket pricing, with the cost remaining the same at every dose.

We do not currently accept insurance, FSA, or HSA. However, we provide clear, upfront out-of-pocket pricing before you commit to the service, and the cost stays consistent with each dose. What you see is what you pay!